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Home > Products > Human Nutrition > TUDCA Tauroursodeoxycholic acid CAS#14605-22-2

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TUDCA Tauroursodeoxycholic acid CAS#14605-22-2

Name: TUDCA Tauroursodeoxycholic acid CAS#14605-22-2
Brand: SINOCHEM PHARMACEUTICAL CO., LTD
Rating: 4.1 (11 reviews)

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Product Description

Tauroursodeoxycholic acid (TUDCA) is an endogenous hydrophilic tertiary bile acid produces in humans at a low level. In ER stress conditions, TUDCA treatment of MSCs (mesenchymal stem cells) reduces the activation of ER stress-associated proteins, including GRP78, PERK, eIF2α, ATF4, IRE1α, JNK, p38, and CHOP, and inhibits the dissociation between GRP78 and PERK, resulting in reduced ER stress-mediated cell death. TUDCA treatment increases PrP^C (Cellular prion protein) expression. TUDCA regulates stem cell differentiation into various lineages such as adipogenic and osteogenic lineages. TUDCA attenuates ER stress, prevents unfolded protein response dysfunction, and stabilizes mitochondria. Under ER stress, treatment with TUDCA significantly increases the expression of BCL-2 and significantly decreases the expression of Bax, cleaved caspase-3, and cleaved PARP-1, compared with that of untreated cells.